Researchers have been able to discover that genetic mutations and exposure to insecticides or pesticides in workplaces interact in such a way that tends to increase the risk of Parkinson's disease, particularly in men.

In maximum cases, the etiology of Parkinson's disease is probable to be multi-factorial, and environmental factors plus their interface with vulnerability genes are measured to make contribution to the disease, the authors wrote.

Men exposed to definite kind of pesticides, which includes organochlorines for example DDT, have been seen to develop Parkinson's disease via damage to neurons that generate the neurotransmitter dopamine.

The gene ABCB1 may program the construction of compounds, which are necessary to this procedure.

In a study of 207 individuals with Parkinson's disease typified as never users, users for gardening and professional users of pesticides, the researchers established that the association between organochlorine insecticide exposure and Parkinson's disease was just about 3.5 times higher in men who carried two variant alleles, gene copies, as contrasted with those who were not carriers.

Based on a biological theory, it is shown in the study that organochlorine insecticides might act together with ABCB1 in determining the peril of Parkinson's disease seen in patients getting exposed to such insecticides.