Skelton structure has connection with fertility in male mice. As per the researchers at Columbia University Medical Center, male mice whose skeleton does not release a hormone called osteocalcin are infertile.

Lead author of the study, Gerard Karsenty claims that osteocalcin stimulates the production of testosterone, a sex steroid hormone, regulating fertility in the male mice. When osteocalcin was added to the cells, testosterone production takes a boost and vice-versa.

The newly found association between the fertility and hormone has brought this topic of research into limelight.

Citing the connection between osteocalcin and fertility, the study has raised doubts over the fact the some men have reported infertility as they are deficient with osteocalcin hormone.

Further, Karsenty claims, "We do not know why the skeleton regulates male fertility, and not female. However, if you want to propagate the species, it's probably easier to do this by facilitating the reproductive ability of males".

Though the study is at preliminary stage, the results have given enough fodder to the researchers to replicate the result in humans. Responding to the study, Gerard reportedly claimed that more evidence needs to be produced to substantiate the findings so that any conclusive result can be deducted to use in actual clinical practices.