A $225 million gift has been given to the University of Pennsylvania by Raymond G. Perelman and his wife Ruth, which is the largest in its history. Mr. Perelman, 93, is a trustee of the school, and is also acting as a president and chairman of the board of RGP Holdings Inc., which is a private company dealing in manufacturing, mining and financial interests.

The amount has been gifted to the University for its Medical School, which will be named as the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania.

“I look at it as Penn Medicine gave me a gift,” Mr. Perelman said. “They offered me an opportunity to have my name on one of the best medical schools in the country.”

Amy Gutmann, who is the president of the university, has also appreciated the effort and said that the Perelmans’ gift was transformational.

“It’s the triple crown for our school of medicine,” she said. “It’s going to enable us to have the best students, with enormously increased financial aid, and to recruit the most eminent faculty and provide extraordinary research.”

According to the plans, the Perelmans’ donation will be used in part, enabling the medical school to increase its financial aid budget by at least 20% for the class entering in 2012.