Adaptive Optics Technique helped in Developing Novel Imaging Technology

Adaptive Optics Technique helped in Developing Novel Imaging Technology

Experts at the Howard Hughes Medical Institute's Janelia Farm Research Campus have developed a new imaging technology that corrects distortions within no time and also increases high-resolution images over large volume of tissue.

These distortions take place as biological samples twist light is such ways that when it return it gets difficult for scientists to interpret information to the microscope. But with help of the new technology, which employs adaptive optics technique, the distortions can be corrected rapidly.

The adaptive technology works in tissues and does not lead to scattering of light. The entire procedure makes it possible for imaging the transparent bodies like zebrafish and the roundworm Caenorhabditis elegans.

Eric Betzig, Janelia group leader, said his team has developed the technology by using adaptive optics strategies. These tactics are generally used by astronomers and ophthalmologists to eliminate similar distortions in their images.

The research team has been able to show how their new technology is able to focus on the details of zebrafish like the branching structures, subcellular organelles of nerve cell present deep in the living brain of the fish. Betzig said their newly developed technology is one of a kind that has taken the application of adaptive optics to microscopy to another level.

"Our technique is really robust, and you don't need anything special to apply our technology. In the future, it could be a very convenient add-on component to commercially available microscopes", affirmed Betzig.

Betzig said they have taken hint from astronomers who use adaptive optics for their work. The cue helped them to use the optics to correct the light-bending heterogeneity of biological tissues.